947-113 Aprotinin Produces Ion Channels in lipid Bilayers
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چکیده
منابع مشابه
Bright ion channels and lipid bilayers.
If we look at a simple organism such as a zebrafish under a microscope, we would see many cells working in harmony. If we zoomed in, we would observe each unit performing its own tasks in a special aqueous environment isolated from the other units by a lipid bilayer approximately 5 nm thick. These confined units are social: they communicate with one another by sensing and responding to the chem...
متن کاملSodium Channels in Planar Lipid Bilayers
Single channel currents of sodium channels purified from rat brain and reconstituted into planar lipid bilayers were recorded . The kinetics of channel gating were investigated in the presence of batrachotoxin to eliminate inactivation and an analysis was conducted on membranes with a single active channel at any given time . Channel opening is favored by depolarization and is strongly voltage ...
متن کاملLipid ion channels.
The interpretation of electrical phenomena in biomembranes is usually based on the assumption that the experimentally found discrete ion conduction events are due to a particular class of proteins called ion channels while the lipid membrane is considered being an inert electrical insulator. The particular protein structure is thought to be related to ion specificity, specific recognition of dr...
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Alzheimer's disease (AD) is the most common type of senile dementia in aging populations. Amyloid β (Aβ)-mediated dysregulation of ionic homeostasis is the prevailing underlying mechanism leading to synaptic degeneration and neuronal death. Aβ-dependent ionic dysregulation most likely occurs either directly via unregulated ionic transport through the membrane or indirectly via Aβ binding to cel...
متن کاملBatrachotoxin-modified sodium channels in planar lipid bilayers. Ion permeation and block
Batrachotoxin-modified, voltage-dependent sodium channels from canine forebrain were incorporated into planar lipid bilayers. Single-channel conductances were studied for [Na+] ranging between 0.02 and 3.5 M. Typically, the single-channel currents exhibited a simple two-state behavior, with transitions between closed and fully open states. Two other conductance states were observed: a subconduc...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1995
ISSN: 0735-1097
DOI: 10.1016/0735-1097(95)92188-b